Acetyl-L-Carnitine 10% Topical Hair Growth Stimulant - 120 mL
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Our pharmaceutical-grade Acetyl-L-Carnitine 10% Hair Growth Stimulant is five times more potent than the carnitine used in the study mentioned below and contains the acetylated form of l-carnitine, which has demonstrated superior absorption and bioavailability in humans.
In a well known German controlled study, L-carnitine extended the growth phase in hair follicles, stimulated the development of cells and inhibited the dying off of cells. According to the study published in the Journal of Dermatological Science, L-carnitine also works in real live humans. The researchers performed their experiment on 51 subjects, aged between 21 and 60, all of whom had mild to severe hair loss.
The researchers got half of their subjects to apply a solution that consisted of 2 percent L-carnitine-L-tartrate to the skin on their head twice a day. The other half used a placebo.
After six months the researchers noticed that, in the experimental group, the number of hairs per square centimetre of skin on the head had increased by 15 percent. There was no increase in the number of hairs in the placebo group.
Hair is produced in the hair follicles, in a process that involves a number of phases. The growth phase is referred to as the anagen phase, and the phase in which hair no longer grows is called the telogen phase. The researchers discovered that applying the fluid that contained L-carnitine L-tartrate caused a shift from the telogen to the anagen phase in the hair follicles.
The trimethylated amino acid l-carnitine plays a key role in the intramitochondrial transport of fatty acids for beta-oxidation and thus serves important functions in energy metabolism. Here, we have tested the hypothesis that l-carnitine, a frequently employed dietary supplement, may also stimulate hair growth by increasing energy supply to the massively proliferating and energy-consuming anagen hair matrix.
Hair follicles (HFs) in the anagen VI stage of the hair cycle were cultured in the presence of 0.5-50 microm of l-carnitine-l-tartrate (CT) for 9 days. At day 9, HFs treated with 5 microm or 0.5 microm of CT showed a moderate, but significant stimulation of hair shaft elongation compared with vehicle-treated controls (P < 0.05). Also, CT prolonged the duration of anagen VI, down regulated apoptosis (as measured by TUNEL assay) and up regulated proliferation (as measured by Ki67 immunohistology) of hair matrix keratinocytes (P < 0.5).
By immunohistology, intrafollicular immunoreactivity for TGFbeta2, a key catagen-promoting growth factor, in the dermal papilla and TGF-beta II receptor protein in the outer root sheath and dermal papilla was down regulated. As shown by caspase activity assay, caspase 3 and 7, which are known to initiate apoptosis, are down regulated at day 2 and day 4 after treatment of HFs with CT compared with vehicle-treated control indicating that CT has an immediate protective effect on HFs to undergo programmed cell death.
Our findings suggest that l-carnitine stimulates human scalp hair growth by up regulation of proliferation and down regulation of apoptosis in follicular keratinocytes in vitro. They further encourage one to explore topical and nutraceutical administration of l-carnitine as a well-tolerated, relatively safe adjuvant treatment in the management of androgenetic alopecia and other forms of hair loss.
Given the superior delivery and bioavailability of the acetylated form of l-carnitine, acetyl-l-carnitine is likely to result in enhanced effects.
Directions For Use
Apply liberally to a dry scalp using the accompanying applicator. Massage into scalp and allow to remain for several hours or overnight. Discontinue if irritation occurs.